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ANAXAM Technology Centre in collaboration with Merck & Co., Inc., investigated the mechanisms of needle clogging in pre-filled syringes, focusing on zinc (Zn) ions, which have been reported to promote protein gelation and increase formulation viscosity.

ANAXAMs analytics with Synchrotron X-ray tomography help to understand the impact of syringe clogging on the distribution of drug in the tissue. The investigation has been done in collaboration with our customer Novartis.

We are happy to announce that our paper “Microstructures, phase and mechanical characterisation of Al2O3-ZrO2-TiO2 coating produced by atmospheric plasma spraying” is accepted to Open Ceramics. For this publication we worked together with Armando Salito (Gulhfi AG), Michael de Wild & Lukas Graf (FHNW), Margie Olbinado & Michal Andrzejewski (PSI), Susanne Erpel & Alexander Vogel & Marcus Wyss (SNI), Geoffrey Darut (CNRS) and Simon Bode (KIT).

Cosmic ray testing is usually performed with the gate electrode shortened to the emitter ground, producing zero electric field across the gate dielectric oxide. In real applications, the gate is usually charged to +/-15 V with respect to the emitter, resulting in a field strength exceeding 100 kV/mm. This work aims to test the effect of a gate voltage applied on the failure in time (FIT) rate of Trench Si-IGBTs irradiated with protons and neutrons, providing more realistic test conditions close to the application. Further, HTGB tests are performed on the surviving devices to provide novel insights into the impact of cosmic ray particles on the gate oxide reliability.

ANAXAMs analytics with Neutrons and Synchrotron X-rays help to understand the clogging phenomena in pre-filled syringes. The study aimed to investigate the movement of liquid in the needle region of staked-in-needle pre-filled syringes using neutron radiography and synchrotron X-ray tomography. The investigation has been done in collaboration with our customer Merck & Co., Inc.

As part of a joint development project between Audi Sport, the Paul Scherrer Institute and ANAXAM, a tailor-made test bench for dynamic neutron radiography was realised. In close cooperation with Audi Sport, the test bench was designed and subsequently constructed, manufactured and commissioned by ANAXAM. The test bench is designed in such a way that relevant parameters can be dynamically adjusted during the test. This means that real driving conditions can be simulated well on the test bench. The measurements were then carried out at the NEUTRA beamline of the SINQ spallation neutron source at PSI.

The aim of the joint project was to visualise the micromovements of brake pistons non-destructively and to analyse them in more detail.