High-resolution 3D visualisation of the blockage using Synchrotron CT
Synchrotron CT is a high-resolution 3D Imaging method for analysing interfaces between air and liquid inside a needle. The method allows over 100 syringes to be analysed per day.
3D Synchrotron CT


2D visualisation of the blockage using Neutron Radiography
Neutron Radiography is a 2D Imaging method for analysing the presence of drugs inside a needle. The method makes it possible to examine over 100 syringes per day.
2D Neutron Radiography


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Success stories

Dr. Liliya Vladislavova,
Product Engineer
Using the advanced methods offered by ANAXAM enables us to gain new perspectives in the field of imaging techniques. With the help of Neutron radiography and Synchrotron CT, we want to expand our knowledge of making the next generation of drug containment and delivery solutions safer and easier to use.”

Dr. Guangli Hu,
Principal Scientist, Device Development
The combination of neutron imaging and synchrotron X-ray tomography provided valuable insights into the dynamics of liquid movement in staked-in-needle pre-filled syringes. The detailed morphological analysis enhanced the understanding of microstructural arrangements within the needle. This research contributes to addressing the issue of needle clogging and can guide the development of strategies to improve pre-filled syringe performance significantly.”

Dr. Alexander Zürn,
Associate Director Advanced Testing Global Device & Packaging Development
We can only really understand many phenomena through visualisation. Visualising the behaviour of injected drugs in tissue is an important way of understanding the influence a blocked needle can have on the injection, which we have now been able to achieve in this research project. Imaging techniques, especially synchrotron X-ray tomography, made this possible in an impressive way that has never been shown before. 3D images provide even more information and show a really clear model of the injection mechanism. The great expertise of the entire interdisciplinary team made this possible.”
Answers to the most frequently asked questions
Our analytical methods can be applied to all types of pre-filled syringes and autoinjectors.
Clogging is detected by high-resolution Synchrotron CT and Neutron Radiography.
Neutron Radiography enables two-dimensional visualisation of the fluid within the needle under varying environmental conditions, which helps to identify the causes of clogging.
Synchrotron CT offers high-resolution three-dimensional imaging that provides detailed insights into the interfaces between air and liquid within the needle and can thus reveal the causes of clogging.
Yes, of course. We are here to advise you without obligation and to find out whether we can support you. Please do not hesitate to contact us.
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