Tailor-made infrastructure for real-time investigation of the dissolution behaviour of tablets using Synchrotron CT

During manufacturing
Volume flow min.
0
nl/min
Volume flow max.
0
ml/min
pH value of the solution
adjustable
Year of manufacture
0
Control
Volume flow
Branche
Medical technology

Functional highlights

  • Measuring cell to fix and rinse the tablet

  • High-precision volume flow control using syringe pumps

  • Rotary liquid feed-through for tomography measurements

  • Temperature accuracy: ± 0.5°C

  • Syringe pump volume: 50 ml

  • Volume flow range: 38 nl/min - 300 ml/min


Infrastructure process from conception to operation

• Measuring cell to fix and rinse the tablet

• Highly precise and adjustable volume flow

• Possibility for tomography measurements

Tabletten_Konzeption
Figure 1: Concept for dissolving tablets

•  Measuring cell with grid bottom for ideal rinsing around the tablet 

•  High-precision volume flow controlled by syringe pumps

•  Rotary liquid feed-through for tomography measurements

Tabletten_Konstruktion
Figure 2: Design of the infrastructure

•  Production of the measuring cell using 3D printing process 

•  Installation and commissioning of the hardware and software

•  Controller tuning and acceptance tests in the laboratory

Tabletten Inbetriebnahme
Figure 3: Commissioning

•  Setting up the tablet dissolution infrastructure at the beam line

•  Setting up the software for interface communication

•  Carrying out the customer-specific experiments

Tabletten im Einsatz
Figure 4: Tablet dissolution infrastructure in use at the beamline
During manufacturing
Volume flow min.
0
nl/min
Volume flow max.
0
ml/min
pH value of the solution
adjustable
Year of manufacture
0
Control
Volume flow
Branche
Medical technology

Tailor-made infrastructure for real-time investigation of the dissolution behaviour of tablets using synchrotron CT

Any question? Feel free to contact us